John Hemming's Web Log

Please see Interleukin-10 Review of Research

Please see Gompertz, Interleukin-10 and the gradual deterioration of health .

This blog post is another work in progress. In it I intend to consider the research on HIF and what the possible models are that lead from varying partial pressures of Oxygen in breathed gas (and the time of exposure) and the various possible outcomes (HIF, NRF2 and NF-κB). I shall aim to write this for people who have some scientific knowledge with links to the research. If you are reading this and would like me to expand on an explanation please comment. Disclaimer: This is not medical advice. Before you decide to do anything get advice from your doctors. Different people are affected in different ways and expert advice on your own personal circumstances is needed. Glucose and Oxygen Cells in animals generate energy as a molecule called ATP (Adenosine Tri Phosphate). This can be done in a number of ways. Generally the process starts with Glucose (ignoring for now when the body is using Ketones). If there is enough Oxygen then a process called Oxidative phosphorylation oc...

As part of my work on sleep and health I have been researching why cells deteriorate. There is a lot of good research out there, but I think now it is possible to see a reinforcing vicious circle that is at the core of many deteriorations in health. I think what happens is that an increase in inflammation causes a reduction in NF-κb which causes a reduction in SLC25A1 which reduces the number of citrate carriers which causes the differentiation of stem cells to fail more often and those turn in to senescent cells which then increases inflammation. Obviously those would not be all senescent cells, but I think it would be a substantial proportion. Noting that the Naked Mole Rats don't really have that many it is consistent. Please note that it is the level of NF-κb in the Stem Cells which will be key in setting the state of the Citrate Carrier. I have done a video that looks quickly at this and how people can try to improve their cellular health. Inflammation ꜛ ->NF-κb ꜜ ...

I think over time people will expect, of course, to take some form of Senolytic to clear out zombie cells. Senescent cells are cells which are the living dead of the body. They are not healthy enough to function, but they are also not ill enough to actually die off. Ideally the immune system will clear them out and although they are sterile they often send out inflammatory markers and create one of the major burdens of the bodys immune system. This inflammation puts a load on the body which depletes levels of NAD which then has a reinforcing effect in that the body has less energy to clear them out and they are more likely to be created. Senolytics like Fisetin and Quercetin are molecules (those two are from plants such as Strawberries - Fisetin) which make it more likely that the body will clear out the zombie cells. I have recently done some experimentation with both of them. I have concluded that Fisetin can have a side effect of harming sleep. The pattern it creates is one ...

Quite a few people know I have been putting some effort into debugging my metabolism. This in many ways is medical research where N=1, but actually is different to most medical research. Rather an apply a protocol for a period of weeks or months and measure the results I apply different protocols almost on a daily basis. I do, of course, measure the results. However, rather than experimenting with one protocol this enables me to try lots of different protocols. On my youtube channel I then aim to publish short videos with my conclusions. Recently, for example, I have experimented with Ketone Ester to see whether the GABAergic impact of the ketone is more or less influential than the increased energy available to neurons and experimented with acetylsalicylic acid (Aspirin) to see if I can prevent the Cortisol Awakening Response from keeping me awake during the night by disabling the Cycoloxegenase-1 enzyme whilst re-enabling the enzyme sufficiently to create adenosine and Melatonin...

I have recently done another video about Melatonin. On my blog entry about insomnia I go into some links relating to Melatonin. It is clear, however, that Melatonin is a key for reducing the decay that occurs in cells. At the moment I am trying to set up a trial into the use of melatonin for improving cellular health reversing the entropic decay that occurs over time (cellular aging). If anyone is interested in participating in such a trial they should email me. melatonin site

Many people remember the saga in the past about Green Waste. I took a court case out against the City Council and the City Cleared up the waste, but the court decided to award costs against me. I took this through an appeal in the Admin Court and a second appeal in the Court of Appeal (both of which I lost). I then took it to the Aarhus Convention Compliance Committee where this week I won. The details are here: https://unece.org/env/pp/cc/accc.c.2016.142_united-kingdom It is quite significant as it requires the UK to change its procedures so that people can safely challenge public authorities on environmental issues without worrying about being hit by a hefty costs bill. The fact is that there were two other people hit by this in the UK and it had shut down one local environmental charity because of the impact.

Taking the figures on 8th June vs 1st June we have: Area 1st 8th England 115 147 East 7 6 London 29 20 Midlands 18 40 North East 17 18 North West 31 43 South East 10 13 South West 3 7 The North west shows a more general recent growth. The figures by trust are only up to 6th June not 8th June. They do show a recent wave of admissions in Bolton peaking at 14 people on 25th May. Manchester also had a peak of admissions on 5th June at 18. Otherwise nationally there have been double digit admissions in the week to 6th June in East Lancashire and Bedfordshire. Both of those, however, reduced from the prior week. Hence the recent growth does appear to be quite localised. However, as the government do not release the figures by trust more frequently than weekly it is difficult to tell precisely what is going on.

Valerian for sleep: a systematic review and meta-analysis 2006 - "The available evidence suggests that valerian might improve sleep quality without producing side effects. Future studies should assess a range of doses of standardized preparations of valerian and include standard measures of sleep quality and safety." Valerian for sleep: a systematic review and meta-analysis 2010 - The AMED and MEDLINE databases were searched for primary sources of literature published between 1950 and 2009, using keywords: herbal medicine, medicinal plants, herbal, Valeriana officinalis, valerian, Humulus lupulus, hops, sleep, insomnia. Studies were included if they evaluated the efficacy of valerian or hops in improving primary insomnia in adults: sixteen studies met the inclusion criteria. Twelve of these found that the use of valerian, on its own, or in combination with hops, is associated with improvements in some sleep parameters (eg. sleep latency and quality of sleep). However, th...

Data last date 14/2/2021 This table reports admissions into hospital trusts for covid in the order of the number of admissions in the last available week compared to the total number of admissions. The idea is to highlight those trusts which are having a high level of admissions that has grown in the past two weeks. Some trusts serve areas where there is a high level of immunity and hence few people being infected. However, some patients are being redirected to other hospitals and we don't necessarily see the same low level of admissions. Total admissions Admissions Last Week Admissions Prior Week Admissions Fortnight first wave Compare last two weeks Percentage of total in last week Black Country Healthcare NHS Foundation Trust 188 16 4 25 Growing 8.5 Hertfordshire Community NHS Trust 253 15 9 15 Growing 5.9 East London NHS Foundation Trust 396 23 6 43 Growing 5.8 Harrogate and District NHS Foundation Trust 689 36 33 64 Growing 5.2 Great Ormond Street Hospital for Children ...