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Showing posts from April, 2023

NAD (Nicotinamide adenine dinucleotide) and aging - does differential expression of KYNU and KMO genes reduce NAD levels.

Nicotinamide adenine dinucleotide (NAD) is a chemical found in cells which is at the centre of many metabolic processes. It has been noted by many people that NAD levels go down as people get older. I won't go into any of the details of the impact of this as it can be read in many other places. This is just one of many articles about this. I am not citing it particularly, but it is one I found in a few second searching on the net. Recently Michael Lustgarten produced a video: I have linked to the video to a point at which the alternative route of producing NAD from Tryptophan is highlighted Most of the discussions about NAD relate to how it is produced from different versions of vitamin B3 which includes NMN and NR. Indeed there have been many debates about what is the best way to increase NAD+. The video got me thinking. The video highlights how there is an increase in the metabolite (3-hydroxy-l-kynurenine) produced by Kynurenine 3-monooxygenase (which is produced