There has been some press attention to Endometriosis recently. To me it looks like a splicing/acetylation type of disease (which requires that sort of intervention to resolve). I have put some prompts into an AI (chatGPT) to produce a more detailed argument with citations and here is the response: Could Endometriosis Result from Aberrant Splicing Caused by Reduced Nuclear Acetylation? Summary: Endometriosis is usually described as an inflammatory, hormonal and fibrotic disease in which endometrial-like tissue grows outside the uterus. However, a growing body of evidence suggests another layer of explanation: endometriosis may involve abnormal RNA splicing, and that abnormal splicing may in some cases arise from reduced acetylation of nuclear proteins. This article sets out the argument for that hypothesis. The evidence does not yet prove that reduced nuclear acetylation is the root cause of endometriosis, but it does make the hypothesis biologically plausible an...
I am collecting links to papers which look at mtDNA damage in human oocytes. Mitochondrial DNA Damage and Its Repair Mechanisms in Aging Oocytes Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction Mitochondrial deoxyribonucleic acid deletions in oocytes and reproductive aging in women Mitochondrial deoxyribonucleic acid deletions in oocytes and reproductive aging in women Mitochondrial DNA point mutation in human oocytes is associated with maternal age Mitochondrial Dysfunction and Age-related Oocyte Quality Allele frequency selection and no age-related increase in human oocyte mitochondrial mutations