The Cortisol Awakening Response (CAR) is managed by the HPA axis and is the process which makes people wake up in the morning so they can get on with the day. At times this happens during the night and can be a real nuisance as people cannot get back to sleep. It is possible using a small amount of Aspirin to disable the CAR (stop the CAR), but that then has knock on effecs on sleep for the next night because of the way Cycoloxegenase-1 reeables (over 36 hours). I am now working on a hypothesis that Melatonin actually tees up the CAR. Hence if you take a large amount of melatonin at say 0.30am you would expect a CAR type of cortisol response about 90 mins later. This is useful as it indicates that larger amounts of melatonin should only be taken in the 2-3 hours before you actually want your CAR to start. (Educational information not medical advice - talk to a healthcare practitioner and this may not work for everyone). It is also possible to stop the CAR with a small dose of A
Quite a few people know I have been putting some effort into debugging my metabolism. This in many ways is medical research where N=1, but actually is different to most medical research. Rather an apply a protocol for a period of weeks or months and measure the results I apply different protocols almost on a daily basis. I do, of course, measure the results. However, rather than experimenting with one protocol this enables me to try lots of different protocols. On my youtube channel I then aim to publish short videos with my conclusions. Recently, for example, I have experimented with Ketone Ester to see whether the GABAergic impact of the ketone is more or less influential than the increased energy available to neurons and experimented with acetylsalicylic acid (Aspirin) to see if I can prevent the Cortisol Awakening Response from keeping me awake during the night by disabling the Cycoloxegenase-1 enzyme whilst re-enabling the enzyme sufficiently to create adenosine and Melatonin