People who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working. Recently, however, there have been three papers produced: Aging is associated with a systemic length-associated transcriptome imbalance Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription and Gene Size Matters: An Analysis of Gene Length in the Human Genome From these it is obvious to see that the genes that stop working are the longer ones. To me it is therefore obvious that if there is a shortage of nuclear Acetyl-CoA then it would mean that the probability of longer Genes being transcribed would be reduced to a greater extent than shorter ones.
Comments
I have heard a number of people questioning if you will be remaining as a councillor, indeed if you can remain so. There seems to be a wide spread belief that one cannot legally be both an MP and a councillor.
Do you have any comments on this?
Lots of people don't understand the law or indeed the nature of political office which is more a process of constitutional power mixed with platform. Neither are "jobs" in a traditional sense. I have never taken any money from my role as a City Councillor in any event.
Ian Paisley is renowned for having had pretty much the complete set. He's been a parish councillor, member of the NI Assembly, MP and MEP all at one go. Not that I'd be prepared to try and stop him - he's renowned for having the largest personal vote in the UK, if not Europe. About the only post he hasn't held is Pope, but I hear he has given up on that one.
:-) :-) :-)
ROTFL
I don't know what 'personal vote' means, but Paisley's old mate Gerry Adams in West Belfast had a bigger majority and a higher percentage of the vote.
Congratulations on the victory - we now have at least three bloggin Lib Dem MPs!