People who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working. Recently, however, there have been three papers produced: Aging is associated with a systemic length-associated transcriptome imbalance Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription and Gene Size Matters: An Analysis of Gene Length in the Human Genome From these it is obvious to see that the genes that stop working are the longer ones. To me it is therefore obvious that if there is a shortage of nuclear Acetyl-CoA then it would mean that the probability of longer Genes being transcribed would be reduced to a greater extent than shorter ones.
Comments
I believe the actions of the Judiciary in the case of injunctions is a bad move backwards to protect the rich and famous. It is under such conditions of secrecy that corruption grows and flourishes as I have observed living in the developing world.
Furthermore Judge Eady's ruling cannot (and should not )be enforced abroad. It therefore degrades respect for the law by making it seem an ass.
I urge you to continue the fight and expose as much as possible in the Commons.
Good luck!
They need to learn about proper generalisations and proper distinctions between who is to be protected: criminals or victims, child snatchers or children, the rich and famous or their lovers...