People who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working. Recently, however, there have been three papers produced: Aging is associated with a systemic length-associated transcriptome imbalance Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription and Gene Size Matters: An Analysis of Gene Length in the Human Genome From these it is obvious to see that the genes that stop working are the longer ones. To me it is therefore obvious that if there is a shortage of nuclear Acetyl-CoA then it would mean that the probability of longer Genes being transcribed would be reduced to a greater extent than shorter ones.
Comments
If you look at the safeguarding board,they always seem to consist of people who have worked or have connections with the local authority.
Most of the child deaths reviews come to the conclusion that there is nothing the LA could have done.
It is laughable.Maybe we could list all of the child deaths and list the quotes where the deaths could not have been foreseen.
Also there were 2 referrals to Social Services about this child,so clearly something could have been done if they did their job properly.