People who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working. Recently, however, there have been three papers produced: Aging is associated with a systemic length-associated transcriptome imbalance Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription and Gene Size Matters: An Analysis of Gene Length in the Human Genome From these it is obvious to see that the genes that stop working are the longer ones. To me it is therefore obvious that if there is a shortage of nuclear Acetyl-CoA then it would mean that the probability of longer Genes being transcribed would be reduced to a greater extent than shorter ones.
Comments
No-one likes europop anymore other than the silly buggers who vote to select the UK entry.
No-one else - not even the Scandis - tried europop this year.
I was fully expecting nul points when Ireland and Malta saved the day. Good for them! (and tactical voting) Perhaps when the UK has a decent entry, we'll get a few points.
I would not have been surprised if they had ended up with zilch.
Goodness knows what they have ben putting in the water in Malta!
You try and compete in industry.
Our products are like our Euro pop entry...of better quality.
The eastern block products are tacky and of lower quality.
Yet we buy their products ...because they are cheap.
I would say a decent analogy all round.