People who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working. Recently, however, there have been three papers produced: Aging is associated with a systemic length-associated transcriptome imbalance Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription and Gene Size Matters: An Analysis of Gene Length in the Human Genome From these it is obvious to see that the genes that stop working are the longer ones. To me it is therefore obvious that if there is a shortage of nuclear Acetyl-CoA then it would mean that the probability of longer Genes being transcribed would be reduced to a greater extent than shorter ones.
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That image did remind me of a conversation some of my work collegues and I had last week. We were discussing where parliament would move to when London is too badly flooded and has to be abandoned. Birmingham would be the obvious location due to being built on a hill, our transportation network and the fact that we already have 3 venues that could be easily adapted to accomodate the government.
A number of people did comment, however, that the rampant Brummiephobia that seems to infest the south east would mean that Manchester would be a more likely relocation site.