John Hemming's Web Log

There has been some press attention to Endometriosis recently. To me it looks like a splicing/acetylation type of disease (which requires that sort of intervention to resolve). I have put some prompts into an AI (chatGPT) to produce a more detailed argument with citations and here is the response: Could Endometriosis Result from Aberrant Splicing Caused by Reduced Nuclear Acetylation? Summary: Endometriosis is usually described as an inflammatory, hormonal and fibrotic disease in which endometrial-like tissue grows outside the uterus. However, a growing body of evidence suggests another layer of explanation: endometriosis may involve abnormal RNA splicing, and that abnormal splicing may in some cases arise from reduced acetylation of nuclear proteins. This article sets out the argument for that hypothesis. The evidence does not yet prove that reduced nuclear acetylation is the root cause of endometriosis, but it does make the hypothesis biologically plausible an...