People who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working. Recently, however, there have been three papers produced: Aging is associated with a systemic length-associated transcriptome imbalance Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription and Gene Size Matters: An Analysis of Gene Length in the Human Genome From these it is obvious to see that the genes that stop working are the longer ones. To me it is therefore obvious that if there is a shortage of nuclear Acetyl-CoA then it would mean that the probability of longer Genes being transcribed would be reduced to a greater extent than shorter ones.
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And when will she ever see her 7-year old daughter again???
Our online petition got over 200 signatures and 1,000 page views in two days. http://bit.ly/kExfF1
When we have 100,000 signatures we should get a formale debate in Parliament. At this rate in 3 years!
And look at this academic research covering all the players (including your of course) over 3 decades, unique to the UK and Wales: http://bit.ly/kY15Lp