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Election Result: Thursday 8th May 2008

Medway UA, Rochester South and Horsted
Con 1847 (48.7 + 7.2), Lab 819 (21.6 -5.0), LD Viv Parker 767 (20.2 + 3.6), BNP 257 (6.8 + 6.8), Green 104 (2.7 + 2.7), [Medway Ind (0.0 - 6.2)], [UKIP (0.0 - 9.2)].
Majority 1028. Turnout 41%. CON HOLD. Percentage change is since May 2007.

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Its the long genes that stop working

People who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working. Recently, however, there have been three papers produced: Aging is associated with a systemic length-associated transcriptome imbalance Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription and Gene Size Matters: An Analysis of Gene Length in the Human Genome From these it is obvious to see that the genes that stop working are the longer ones. To me it is therefore obvious that if there is a shortage of nuclear Acetyl-CoA then it would mean that the probability of longer Genes being transcribed would be reduced to a greater extent than shorter ones.