People who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working. Recently, however, there have been three papers produced: Aging is associated with a systemic length-associated transcriptome imbalance Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription and Gene Size Matters: An Analysis of Gene Length in the Human Genome From these it is obvious to see that the genes that stop working are the longer ones. To me it is therefore obvious that if there is a shortage of nuclear Acetyl-CoA then it would mean that the probability of longer Genes being transcribed would be reduced to a greater extent than shorter ones.
Comments
Quite. I fully agree with your sentiments that people rarely vote LibDem for positive reasons.
And that's why so much LibDem election material misrepresents other candidates views and opinions; it's all done to increase voter's unhappiness with those decent politicans who put the interests of their constituents above personal political ambition in order to bolster up the "anti" vote and increase the chances of getting a LibDem elected.
Thank you for your succinct explanation of where so much LibDem support actually comes from.
Where I come from (Northern Ireland), there used to be pacts between the two major Unionist parties in particular seats to avoid the Unionist vote being split.
Respect would better backing the Lib Dems in certain seats, and focusing their efforts on seat they can actually win.