It was interesting to read today the proposals from Warwickshire County Council that the city region combined authority for Coventry should be one for Warwickshire as well.
Frankly this is a bit of a no brainer. Warwickshire curls around Coventry and is clearly in the economic city region. It is only people who reside in the Whitehall that believe that Coventry is best placed with Greater Birmingham.
City Regions work as units of devolution if they have essentially economic city regions of a city and its travel to work area. Hence Lichfield, Bromsgrove, Kidderminster, Tamworth and Redditch fit comfortably into the wider Greater Birmingham area, but Coventry does not.
It always caused tensions in the past and will continue to undermine the common interest of a Greater Birmingham City Region if it is continued.
People who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working. Recently, however, there have been three papers produced: Aging is associated with a systemic length-associated transcriptome imbalance Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription and Gene Size Matters: An Analysis of Gene Length in the Human Genome From these it is obvious to see that the genes that stop working are the longer ones. To me it is therefore obvious that if there is a shortage of nuclear Acetyl-CoA then it would mean that the probability of longer Genes being transcribed would be reduced to a greater extent than shorter ones.
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