tag:blogger.com,1999:blog-61797432024-03-10T22:09:25.174+00:00John Hemming's Web Log<a href="http://john.hemming.name/">John Hemming</a>'s Web LogJohn Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.comBlogger2692125tag:blogger.com,1999:blog-6179743.post-18621288814269487522023-12-22T15:55:00.005+00:002023-12-25T08:16:53.184+00:00Epigenetic Age Changes - what do they mean? Has my biological age really gone from 63 to 37?The concept of an Epigenetic Clock has been around for some time. The idea is that there are markers on DNA from which it is possible to work out someone's biological age. The idea of "biological age" is that it is in essence a measurement of how healthy someone is. People with the same chronological age, but different biological ages differ in their health status. My own personal view is John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-90532382720041570162023-10-27T10:23:00.001+00:002023-10-27T10:23:06.705+00:00 Neural Networks IntroductionAs readers may know I have been helped in my court cases over the past few years by Samuel Collingwood Smith. As well as being a law graduate and former councillor, Sam is also a software developer and recently he has begun two article series on artificial intelligence. One focuses on neural networks, one more on the tensor mathematics used in modern AI and neural networks. These are intended to John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com2tag:blogger.com,1999:blog-6179743.post-66215484515319947322023-06-25T07:33:00.003+00:002023-06-25T07:37:52.258+00:00UK Autophagy Network and the importance of autophagy for health (Healthspan and Longevity)On 19-20 June 2023 I attended the conference of the UK Autophagy network. They have a website for the conference here and https://twitter.com/autophagyuk is their twitter account.
This was a really interesting conference. My degree is in Physics specialising in Theoretical, Atomic and Nuclear physics. However, I have spent a lot of time reading up on molecular biology in the last few years. John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-84996570486324405212023-06-10T17:09:00.013+00:002023-07-29T04:59:01.497+00:00HDAC inhibitors and Gene Expression (The Sirtuins are not longevity genes) - Resveratrol etcI have been reading up on the issues around acetylation of the histone and I have some ideas as to the interplay between acetylation and deacetylation.
There are two steps in creating proteins. The first is called "transcription". This is where a complex called RNA Polymerase II (RNA Pol II or RNAPII) travels down the gene creating messenger RNA (mRNA) as essentially a local copy. The second John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-63462477995070629132023-04-17T09:21:00.002+00:002023-04-17T12:21:19.223+00:00NAD (Nicotinamide adenine dinucleotide) and aging - does differential expression of KYNU and KMO genes reduce NAD levels.Nicotinamide adenine dinucleotide (NAD) is a chemical found in cells which is at the centre of many metabolic processes. It has been noted by many people that NAD levels go down as people get older. I won't go into any of the details of the impact of this as it can be read in many other places. This is just one of many articles about this. I am not citing it particularly, but it is one I John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-24291351346185606052023-02-08T20:34:00.000+00:002023-02-08T20:34:16.228+00:00Homes for Lambeth Scandal Reveals Labour Failures and Concerns About Executive Paul SimpsonI came across this story written by a friend about a national scandal that I consider raises issues of concern about the provision of housing for vulnerable groups and Labour failures. According to a report by independent peer Lord Kerslake, "The Kerslake Review", Labour controlled Lambeth council has wasted £25 million funding a failed private housing company, Homes for Lambeth.
Worse, it John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-56937016272476091602023-01-30T13:55:00.009+00:002023-01-31T08:11:25.702+00:00Biohackers: Bryan Johnson, Michael Lustgarten, and myselfBiohacking has come more into the public domain with the publicity around Bryan Johnson's blueprint. Bryan Johnson is someone who is a tech entrepreneur who sold one of his businesses a few years ago and has since being trying to improve his health. This has been described in the media as him spending about USD 2 million a year with try to get his body to be the equivalent of an 18 year olds. John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-60461480416803346042023-01-18T14:16:00.002+00:002023-05-25T17:27:26.213+00:00Why does vitamin D exist - To provide an annual metabolic cycle?We know Vitamin D exists. We know that people suffer if they don't have enough of it. However, it raises an interesting question as to why we evolved to create a vitamin in the summer which gets stored and then gradually fades away during the winter. I have an idea. Historically food was more plentiful in the summer and less available in the winter. The genes that rely on vitamin D don't John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-15284965284634071782022-12-22T10:57:00.013+00:002023-07-24T15:10:20.081+00:00Autophagy, Gene Length and Aging (why Senolytics don't work that well)
Role of autophagy in aging: The good, the bad, and the ugly is a really good review into the function of autophagy (eating yourself) which is how cells tidy themselves up by getting rid of dysfunctional mitochondria and creating new ones. Autophagy is a good thing because it makes cells work better. That almost certainly ups the Acetyl-CoA levels in the nucleus which readers of this blog will John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-33758963219489657572022-12-13T06:44:00.034+00:002024-02-17T07:42:38.440+00:00Its the long genes that stop workingPeople who read my blog will be aware that I have for some time argued that most (if not all) diseases of aging are caused by cells not being able to produce enough of the right proteins. What happens is that certain genes stop functioning because of a metabolic imbalance. I was, however, mystified as to why it was always particular genes that stopped working.
Recently, however, there have beenJohn Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com1tag:blogger.com,1999:blog-6179743.post-21317669613969339972022-11-12T14:30:00.003+00:002022-11-12T14:30:26.551+00:00NMN, Nicotine Riboside and current controversiesThe last few days have been quite interesting in the supplements space. We had the FDA banning NMN and the reports that NR may encourage some forms of cancer.
FDA says ingredient studied as drug—β-NMN—is excluded from supplements is one of a number of stories which explain how the FDA have concluded that NMN is actually excluded.
It wasn't really so much a decision of the FDA actually to ban John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-29541361703910111522022-11-08T16:53:00.006+00:002022-12-24T07:48:16.278+00:00Blood Tests and Biohacking - some personal experiences worth readingI have been working on improving the health of the cells in my body, with some success, for a while now. This year, however, I have decided to monitor the situation with what are essentially weekly blood tests. I started out the year with blood tests every 4 weeks, but in May I moved to weekly tests. Apart from a short period when on holiday I have had at least one blood test each week since John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-77757873663039132862022-08-02T05:52:00.001+00:002022-08-02T06:00:36.844+00:00Balanced Reporting and John Hemming v Sonia PoultonOn Wednesday 13th July there was a hearing in my case against Sonia Poulton. There have been a lot of technical hearings and it has been back and forth with costs going each way. So far, everyone has made a net loss. For example, as MHN points out, there have been a number of mixed costs orders. The difficulty is Sonia only reports the ones that go her way, but fails to mention things that do notJohn Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-9428821211222828952022-07-06T08:18:00.022+00:002023-06-02T06:47:59.162+00:00Interleukin-10 Review of ResearchPart of my hypothesis that there is a feedback mechanism between the failure of Stem Cells to Differentiate and the failure of more Stem cells to differentiate is that failed stem cells (senescent cells) issue a molecule as part of SASP into the blood which then affects other Stem Cells.
I think it is most likely that this molecule is Interleukin-10. (In fact having done the research I think it John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-12767204119421418092022-07-06T08:18:00.021+00:002022-12-27T07:22:25.210+00:00What are the consequences of a shortage of nuclear Acetyl-CoAI am using this page to collate research papers looking at what disease are probably caused by differentation failure. It is at a really early stage at the moment. It has a useful collection of links, but no real analysis.
Atherosclerosis
Mummies reveal that clogged arteries plagued the ancient world Looks like it is not a modern diet
The Role and Research Progress of Inhibitor of John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com3tag:blogger.com,1999:blog-6179743.post-809048112971494422022-07-06T08:18:00.017+00:002022-12-22T11:08:36.473+00:00Gompertz, Interleukin-10 and the gradual deterioration of healthThe Gompertz–Makeham law of mortality is a formula used to predict mortality. The Makeham element is the external part of this such as disease or accidents. The Gompertz part relates to the gradual deterioration of health of an entity. Not all animals follow the Gompertz formula, but Human Beings do. It is an exponential increase in death rates with age.
My view is that this implies that at John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com6tag:blogger.com,1999:blog-6179743.post-18041830963575644272022-06-21T16:08:00.005+00:002022-07-07T13:13:47.347+00:00Protocol which makes senescent cells start to function and hair to growNote this photo:
What you have is three images at different levels of magnification of
some hair cells. These are hair cells which have not produced hair for
some time. I have been doing some experimentation.
As a result of my experimentation I have found a protocol which I believe makes cells which were senescent start to function.
I think there are some side effects with this protocol.John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com4tag:blogger.com,1999:blog-6179743.post-60793877461312554582022-04-30T08:40:00.004+00:002022-07-06T09:56:09.575+00:00Interleukin-10 Review of ResearchPlease see Interleukin-10 Review of ResearchJohn Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-73564411323268247312022-04-28T06:36:00.009+00:002022-07-06T09:54:33.802+00:00Gompertz, Interleukin-10 and the gradual deterioration of healthPlease see Gompertz, Interleukin-10 and the gradual deterioration of health.
John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-49310294341482776762022-03-06T11:05:00.089+00:002022-03-17T10:28:23.528+00:00The Hypoxia Inducible Factor - research on stimulating thisThis blog post is another work in progress. In it I intend to consider the research on HIF and what the possible models are that lead from varying partial pressures of Oxygen in breathed gas (and the time of exposure) and the various possible outcomes (HIF, NRF2 and NF-κB). I shall aim to write this for people who have some scientific knowledge with links to the research. If you are reading John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-24802559183865350482022-02-19T18:30:00.006+00:002022-02-20T11:25:52.055+00:00Why do cells gradually deteriorateAs part of my work on sleep and health I have been researching why cells deteriorate. There is a lot of good research out there, but I think now it is possible to see a reinforcing vicious circle that is at the core of many deteriorations in health. I think what happens is that an increase in inflammation causes a reduction in NF-κb which causes a reduction in SLC25A1 which reduces the number ofJohn Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-31370618454593674082021-12-30T09:49:00.005+00:002021-12-30T09:51:39.799+00:00Fisetin Quercetin and SleepI think over time people will expect, of course, to take some form of Senolytic to clear out zombie cells. Senescent cells are cells which are the living dead of the body. They are not healthy enough to function, but they are also not ill enough to actually die off. Ideally the immune system will clear them out and although they are sterile they often send out inflammatory markers and create John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-18805372277360533512021-11-16T19:34:00.003+00:002021-11-16T19:36:04.152+00:00Debugging the MetabolismQuite a few people know I have been putting some effort into debugging my metabolism. This in many ways is medical research where N=1, but actually is different to most medical research. Rather an apply a protocol for a period of weeks or months and measure the results I apply different protocols almost on a daily basis. I do, of course, measure the results. However, rather than experimenting John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-59655739862643972352021-11-04T19:25:00.006+00:002021-11-08T15:06:53.023+00:00Melatonin - a route towards improved cellular health (reversing cellular aging)I have recently done another video about Melatonin.
On my blog entry about insomnia I go into some links relating to Melatonin. It is clear, however, that Melatonin is a key for reducing the decay that occurs in cells. At the moment I am trying to set up a trial into the use of melatonin for improving cellular health reversing the entropic decay that occurs over time (cellular aging). If John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0tag:blogger.com,1999:blog-6179743.post-38486572019196794242021-07-29T10:53:00.001+00:002021-07-29T10:53:40.362+00:00Victory in the United Nations on Birmingham Green Waste CaseMany people remember the saga in the past about Green Waste. I took a court case out against the City Council and the City Cleared up the waste, but the court decided to award costs against me. I took this through an appeal in the Admin Court and a second appeal in the Court of Appeal (both of which I lost). I then took it to the Aarhus Convention Compliance Committee where this week I won.
John Hemminghttp://www.blogger.com/profile/16563623241172913378noreply@blogger.com0